Convergent Total Syntheses of (−)‐Rubriflordilactone B and (−)‐ pseudo ‐Rubriflordilactone B
نویسندگان
چکیده
منابع مشابه
Total Synthesis of (+)-Rubriflordilactone A.
Two enantioselective total syntheses of the nortriterpenoid natural product rubriflordilactone A are described, which use palladium- or cobalt-catalyzed cyclizations to form the CDE rings, and converge on a late-stage synthetic intermediate. These key processes are set up through the convergent coupling of a common diyne component with appropriate AB-ring aldehydes, a strategy that sets the sta...
متن کاملTotal Synthesis of the Schisandraceae Nortriterpenoid Rubriflordilactone A
Full details of the total synthesis of the Schisandraceae nortriterpenoid natural product rubriflordilactone A are reported. Palladium- and cobalt-catalyzed polycyclizations were employed as key strategies to construct the central pentasubstituted arene from bromoendiyne and triyne precursors. This required the independent assembly of two AB ring aldehydes for combination with a common diyne co...
متن کاملTotal syntheses of subereamollines A and B.
The first total syntheses of (+)- and (-)-subereamollines A and B are reported. The enantiomeric forms of the natural products were obtained by preparative chiral HPLC separation of the corresponding racemates.
متن کاملA convergent total synthesis of hemibrevetoxin B.
A convergent biomimetic synthesis of hemibrevetoxin B from d-glucal and d-arabinose utilizes an electrophile-promoted cascade anti-Baldwin cyclization of an epoxy alcohol. The epoxy alcohol arises from a palladium-catalyzed coupling of a highly functionalized organozinc compound and an alkenyl iodide, which serve as two chiral building blocks of similar size and complexity. This first successfu...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2019
ISSN: 1433-7851,1521-3773
DOI: 10.1002/anie.201908917